Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

• Le Thi Le,
• Hue Thi Nguyen,
• Liem Thanh Nguyen,
• Huy Quang Tran and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7

• -release behavior of BBR from the electrospun PLA nanofiber scaffold, regarding drug–polymer compatibility and hydrophobicity of the scaffold. Besides, the antibacterial activity of these scaffolds relating to the release of BBR during 24 h was examined against methicillin-resistant Staphylococcus aureus

• (MRSA). The PLA nanofiber scaffold loaded with hydrophilic BBR nanoparticles showed faster BBR release compared with that of the hydrophobic BBR powder-loaded scaffold, resulting in better inhibitory effects against MRSA. The findings of this study suggest controlled drug-release profiles from nanofiber

Antibacterial activity of a berberine nanoformulation

• Hue Thi Nguyen,
• Tuyet Nhung Pham,
• Anh-Tuan Le,
• Nguyen Thanh Thuy,
• Tran Quang Huy and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2022, 13, 641–652, doi:10.3762/bjnano.13.56

• bacterial cell membrane and inhibiting the synthesis of proteins and DNA [15]. Chu et al. [16] reported that BBR showed no antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) in the range of concentrations from 1 to 64 µg/mL. However, inhibition of MRSA biofilm formation was

• from Titan Biotech, India. Bi-distilled water from a Milli-Q system (18.2 MΩ·cm at 25 °C) was used. All other chemicals were of analytical grade and used without further purification. Two bacterial strains isolated from clinical samples, namely, methicillin-resistant Staphylococcus aureus (MRSA) and

Luminescent gold nanoclusters for bioimaging applications

• Nonappa

Beilstein J. Nanotechnol. 2020, 11, 533–546, doi:10.3762/bjnano.11.42

• are presented. In each section representative early examples along with the recent examples are discussed. Biosensing and imaging of pathogens Chan et al. reported human serum albumin (HSA)-stabilized gold NCs (Au-HSA) for sensing Staphylococcus aureus (SA) and methicillin-resistant Staphylococcus

• aureus (MRSA) bacterial strains [83]. The resulting Au-HSA NCs showed reddish PL. The ability of HSA to bind and chelate various ions as well as small molecules was exploited to design a NC-based assay. The directly synthesized Au-HAS NCs showed binding affinities for SA and MRSA strains (Figure 2). A

Ultrastructural changes in methicillin-resistant Staphylococcus aureus induced by positively charged silver nanoparticles

• Dulce G. Romero-Urbina,
• Humberto H. Lara,
• J. Jesús Velázquez-Salazar,
• M. Josefina Arellano-Jiménez,
• Eduardo Larios,
• Anand Srinivasan,
• Jose L. Lopez-Ribot and
• Miguel José Yacamán

Beilstein J. Nanotechnol. 2015, 6, 2396–2405, doi:10.3762/bjnano.6.246

• aureus. Future research should focus on defining the related molecular mechanisms and their importance to the antimicrobial activity of silver nanoparticles. Keywords: electron microscopy; methicillin-resistant Staphylococcus aureus (MRSA); positively charged nanoparticles; silver nanoparticles

• resistance against almost all antibiotics [3]. As penicillin and other β-lactams were previously very efficient antibiotics in treating staphylococcal infections, the prevalent resistance of methicillin-resistant Staphylococcus aureus (MRSA) has made therapy continuously more complex [4]. S. aureus has also